Improving the Quality of 3DEM Biological Information by the Use of New Advanced Reconstruction Algorithms
Carlos Óscar Sanchez Sorzano, EPFL LIB

Test Run • 06 May 2005

Abstract
The knowledge of the spatial conformation of a biological macromolecule is key for understanding the mechanisms involved in its interaction with other particles. 3D Electron Microscopy is a structural technique with a wide range of applications. However, the produced images suffer from a high level of noise and strong distortions introduced by the electron microscope. In this context, robust image processing algorithms are essential to reliably extract the spatial information. In this talk some improvements on the 3D reconstruction step and their posterior application to experimental data will be presented.