EPFL
 Biomedical Imaging GroupSTI
EPFL
  Publications
English only   BIG > Publications > Cryo-EM


 CONTENTS
 Home Page
 News & Events
 Members
 Publications
 Tutorials and Reviews
 Research
 Demos
 Download Algorithms

 DOWNLOAD
 PDF
 Postscript
 All BibTeX References

Inner-Loop-Free ADMM for Cryo-EM

L. Donati, E. Soubies, M. Unser

Proceedings of the Sixteenth IEEE International Symposium on Biomedical Imaging (ISBI'19), Venice, Italian Republic, April 8-11, 2019, in press.

Please do not bookmark the "In Press" papers as content and presentation may differ from the published version.


Thanks to recent advances in signal processing, the interest for fast ℓ1-regularized reconstruction algorithms in cryo-electron microscopy (cryo-EM) has intensified. The approaches based on the alternating-direction of multipliers method (ADMM) are particularly well-suited due to the prime convergence speed and flexibility of use of this algorithm. Yet, the standard ADMM scheme still relies on a nested conjugate gradient (CG) to solve the linear step in its alternating-minimization procedure, which can be costly when handling large-scale problems. In this work, we present an inner-loop-free ADMM algorithm for 3D reconstruction in cryo-EM. By using an appropriate splitting scheme, we are able to avoid the use of CG for solving the linear step. This leads to a substantial increase in algorithmic speed, as demonstrated by our experiments.

© 2019 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from IEEE.
This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder.