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Overview of the Predictive Value of Quantitative 18 FDG PET in Head and Neck Cancer Treated with Chemoradiotherapy

J. Castelli, B. De Bari, A. Depeursinge, A. Simon, A. Devillers, G.R. Jimenez, J. Prior, M. Ozsahin, R. de Crevoisier, J. Bourhis

Critical Reviews in Oncology/Hematology, vol. 108, pp. 40-51, December 2016.


18 F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) allows to quantify the metabolic activity of a tumor (glycolysis) and has become a reference tool in oncology for the staging, restaging, radiotherapy planning and monitoring response in many cancers. Quantitative analyses have been introduced in order to overcome some of the limits of the visual methods, allowing an easier and more objective comparison of the inter- and intra-patients variations. The aims of this review were to report available evidences on the clinical value of quantitative PET/CT parameters in HNC.

Forty-five studies, for a total of 2928 patients, were analyzed. Most of the data available dealt with the intensity of the metabolism, calculated from the Standard Uptake Value (SUV). Metabolic Tumor Volume(MTV) was well correlated with overall survival and disease free survival, with a higher predictive value than the maximum SUV. Spatial distribution of metabolism and textural analyses seems promising.

@ARTICLE(http://bigwww.epfl.ch/publications/castelli1601.html,
AUTHOR="Castelli, J. and De Bari, B. and Depeursinge, A. and Simon, A.
	and Devillers, A. and Jimenez, G.R. and Prior, J. and Ozsahin, M.
	and de Crevoisier, R. and Bourhis, J.",
TITLE="Overview of the Predictive Value of Quantitative 18 {FDG} {PET}
	in Head and Neck Cancer Treated with Chemoradiotherapy",
JOURNAL="Critical Reviews in Oncology/Hematology",
YEAR="2016",
volume="108",
number="",
pages="40--51",
month="December",
note="")

© 2016 Elsevier. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from Elsevier. This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder.
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