EPFL
 Biomedical Imaging GroupSTI
EPFL
  Publications
English only   BIG > Publications > Myocardial Perfusion


 CONTENTS
 Home Page
 News & Events
 People
 Publications
 Tutorials and Reviews
 Research
 Demos
 Download Algorithms

 DOWNLOAD
 PDF
 Postscript
 All BibTeX References

Improvement in the Quantification of Myocardial Perfusion Using an Automatic Spline-Based Registration Algorithm

C. Dornier, M.K. Ivancevic, P. Thévenaz, J.-P. Vallée

Journal of Magnetic Resonance Imaging, vol. 18, no. 2, pp. 160-168, August 2003.



Purpose: To improve the quantification of myocardial perfusion by registering the time series of magnetic resonance (MR) images with injection of gadolinium.

Materials and Methods: Eight patients underwent MR scans to perform myocardial perfusion exam. Two short axis views of the left ventricle (LV) were acquired in free breathing. Two masks for performing the spatial registration of the images were evaluated. The registration was based on pixel intensity in a multi-resolution scheme. The efficiency of this correction was evaluated by calculating geometric residual displacement of the LV and by fitting the data to a compartment model fit with two parameters: K1, the blood-to-myocardium transfer coefficient, and Vd, the distribution volume of the contrast media.

Results: The registration stage allowed a decrease in the observed motion of the LV from more than 1.98 ± 0.68 mm to less than 0.56 ± 0.18 mm (mean ± SD). Variability obtained in the perfusion analysis decreased from 46 ± 103% to 5 ± 4% for K1 parameter and from 18 ± 21% to 5 ± 5% for Vd parameter.

Conclusion: As with manual correction, this automatic motion correction leads to accurate perfusion parameters in dynamic cardiac MR imaging after contrast agent injection. This automatic stage requires placing only one mask over one frame of the perfusion study instead of manually shifting each image to fit a reference image of the perfusion study.


@ARTICLE(http://bigwww.epfl.ch/publications/dornier0301.html,
AUTHOR="Dornier, C. and Ivancevic, M.K. and Th{\'{e}}venaz, P. and
        Vall{\'{e}}e, J.-P.",
TITLE="Improvement in the Quantification of Myocardial Perfusion
        Using an Automatic Spline-Based Registration Algorithm",
JOURNAL="Journal of Magnetic Resonance Imaging",
YEAR="2003",
volume="18",
number="2",
pages="160--168",
month="August",
note="")

© 2003 Wiley-Liss, Inc. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from Wiley-Liss, Inc.
This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder.