Biomedical Imaging GroupSTI
English only   BIG > Publications > MRI Study

 Home Page
 News & Events
 Tutorials and Reviews
 Download Algorithms

 All BibTeX References

A Multi-Contrast MRI Study of Microstructural Brain Damage in Patients with Mild Cognitive Impairment

C. Granziera, A. Daducci, A. Donati, G. Bonnier, D. Romascano, A. Roche, M. Bach Cuadra, D. Schmitter, S. Klöppel, R. Meuli, A. von Gunten, G. Krueger

NeuroImage: Clinical, vol. 8, pp. 631-639, 2015.

Objectives: The aim of this study was to investigate pathological mechanisms underlying brain tissue alterations in mild cognitive impairment (MCI) using multi-contrast 3 T magnetic resonance imaging (MRI).

Methods: Forty-two MCI patients and 77 healthy controls (HC) underwent T1/T2* relaxometry as well as Magnetization Transfer (MT) MRI. Between-groups comparisons in MRI metrics were performed using permutation-based tests. Using MRI data, a generalized linear model (GLM) was computed to predict clinical performance and a support-vector machine (SVM) classification was used to classify MCI and HC subjects.

Results: Multi-parametric MRI data showed microstructural brain alterations in MCI patients vs HC that might be interpreted as: (i) a broad loss of myelin/cellular proteins and tissue microstructure in the hippocampus (p ≤ 0.01) and global white matter (p < 0.05); and (ii) iron accumulation in the pallidus nucleus (p ≤ 0.05). MRI metrics accurately predicted memory and executive performances in patients (p ≤ 0.005). SVM classification reached an accuracy of 75% to separate MCI and HC, and performed best using both volumes and T1/T2*/MT metrics.

Conclusion: Multi-contrast MRI appears to be a promising approach to infer pathophysiological mechanisms leading to brain tissue alterations in MCI. Likewise, parametric MRI data provide powerful correlates of cognitive deficits and improve automatic disease classification based on morphometric features.

AUTHOR="Granziera, C. and Daducci, A. and Donati, A. and Bonnier, G. and
        Romascano, D. and Roche, A. and Bach Cuadra, M. and Schmitter, D.
        and Kl{\"{o}}ppel, S. and Meuli, R. and von Gunten, A. and Krueger,
TITLE="A Multi-Contrast {MRI} Study of Microstructural Brain Damage in
        Patients with Mild Cognitive Impairment",
JOURNAL="NeuroImage: Clinical",

© 2015 Elsevier. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from Elsevier.
This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder.