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Aging Studies on Normal Lens Using the Scheimpflug Slit-Lamp Camera

K. Kashima, B.L. Trus, M. Unser, P.A. Edwards, M.B. Datiles

Investigative Ophthalmology and Visual Science, vol. 34, no. 1, pp. 263-269, January 1993.


PURPOSE. To study the changes in density and thickness in normal lenses related to aging, and to study changes in anterior chamber depth related to aging.

METHODS. Eighty nine normal volunteers (ages 9-80 yr) were examined and their eyes were photographed to obtain Scheimpflug photographs. The images were digitized and linear densitometry was performed, dividing the lens into five areas: posterior capsular (area 1), posterior cortical (area 2), nuclear (area 3), anterior cortical (area 4), and anterior capsular (area 5). Total lens thickness and anterior chamber depth were similarly measured for 90 normal eyes from the densitometry profiles. These were correlated with age.

RESULTS. There was a strong positive correlation between increasing age and the density in all lens areas (area 2: r = 0.805; P < 0.0001; area 3: r = 0.836, P < 0.0001; area 4: r = 0.767, P < 0.0001; and area 5: r = 0.319, P < 0.0023), except the posterior capsular area, where correlation was negative (area 1: r = -0.426; P < 0.0001). In addition, there was a significant correlation between age and overall lens thickness (r = 0.756; P < 0.0001), thickness of nucleus (r = 0.543; P < 0.0001), and cortex (r = 0.632; P < 0.0001), and a negative correlation with anterior chamber depth (r = -0.513, P < 0.0001).

CONCLUSION. This report shows human lens changes in density and thickness correlated with aging using Scheimpflug photography and image analysis techniques. The results will aid future development of systems for automated detection, classification, and monitoring of human cataracts, as well as other anterior segment disorders.

@ARTICLE(http://bigwww.epfl.ch/publications/kashima9302.html,
AUTHOR="Kashima, K. and Trus, B.L. and Unser, M. and Edwards, P.A.
	and Datiles, M.B.",
TITLE="Aging Studies on Normal Lens Using the {S}cheimpflug
	Slit-Lamp Camera",
JOURNAL="Investigative Ophthalmology and Visual Science",
YEAR="1993",
volume="34",
number="1",
pages="263--269",
month="January",
note="")
© 1993 Investigative Ophthalmology and Visual Science. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from Investigative Ophthalmology and Visual Science. This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder.
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