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Magnetic Resonance Spectroscopy Imaging with Field Inhomogeneity Compensation

I. Khalidov, D. Van De Ville, M. Jacob, F. Lazeyras, M. Unser

Proceedings of the 2005 Annual Meeting of the Swiss Society for Biomedical Engineering (SSBE'05), Lausanne VD, Swiss Confederation, September 1-2, 2005, pp. F12.

Magnetic resonance spectroscopic imaging (MRSI) offers the possibility to study the distribution of specific metabolites in the brain. In practice, its potential is limited by the low spatial resolution due to long acquisition times used to sample the chemical shift information. In this case of sparse spatial sampling, traditional Fourier reconstruction is impaired by voxel “bleeding”. Constrained reconstruction method [1, 2] has been proposed for fitting low-resolution measures to high-resolution compartments that are obtained a priori, e.g., from a segmented proton image. Nevertheless, constrained reconstruction methods are unfeasible in typical 1H spectroscopy, since the effect of the B0 field inhomogeneity is too important, even after shimming.


  1. E.M. Haacke, Z.-P. Liang, S.H. Izen, "Constrained Reconstruction: A Superresolution, Optimal Signal-to-Noise Alternative to the Fourier Transform in Magnetic Resonance Imaging," Medical Physics, vol. 16, no. 3, pp. 388-397, May 1989.

  2. K.A. Wear, K.J. Myers, S.S. Rajan, L.W. Grossman, "Constrained Reconstruction Applied to 2-D Chemical Shift Imaging," IEEE Transactions on Medical Imaging, vol. 16, no. 5, pp. 591-597, October 1997.

AUTHOR="Khalidov, I. and Van De Ville, D. and Jacob, M. and Lazeyras, F.
        and Unser, M.",
TITLE="Magnetic Resonance Spectroscopy Imaging with Field Inhomogeneity
BOOKTITLE="Proceedings of the 2005 Annual Meeting of the {S}wiss Society
        for Biomedical Engineering ({SSBE'05})",
address="Lausanne VD, Swiss Confederation",
month="September 1-2,",

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