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Improved Reconstruction of Frequency-Domain Optical-Coherence Tomograms (FDOCT)

Investigators: Chandra Sekhar Seelamantula

Summary: FDOCT is an optical imaging modality that is suitable for fast imaging of thin biological specimens (thickness of the order of a few millimeters, resolution of the order of a few micrometers). The conventional reconstruction techniques give rise to some objectionable artifacts, which limit the efficiency of the modality. We have developed new techniques for artifact-free, high-fidelity tomogram reconstruction in FDOCT.

Main Contributions

The key contributions of our work are: 1) the development of a new nonlinear, noniterative technique that significantly suppresses the autocorrelation artifacts; and 2) a new method to acquire data and to perform reconstruction without complex-conjugate ambiguity. The first technique is based on a cepstrum approach for tomogram reconstruction and the second one employs a combination of Hilbert and Fourier transforms. The theoretical aspects of the two techniques have been investigated and extensive validation on synthesized as well as real-world experimental data has been carried out. Our investigations showed that the proposed techniques offer a significant improvement in reconstruction quality. The techniques are also quite fast; the associated computational complexity is comparable to that of the conventional Fourier-transform technique.

Collaborations: Prof. Michael Unser, Prof. Rainer Leitgeb (Medical University of Vienna), Prof. Theo Lasser and Martin Villiger (LOB)

Period: 2006-ongoing

Funding: Center for Biomedical Imaging (CIBM)

Major Publications

[1] 

C.S. Seelamantula, M. Unser, "Performance Analysis of Reconstruction Techniques for Frequency-Domain Optical-Coherence Tomography," IEEE Transactions on Signal Processing, vol. 58, no. 3, pp. 1947-1951, March 2010.

[2] 

C.S. Seelamantula, M.L. Villiger, R.A. Leitgeb, M. Unser, "Exact and Efficient Signal Reconstruction in Frequency-Domain Optical-Coherence Tomography," Journal of the Optical Society of America A, vol. 25, no. 7, pp. 1762-1771, July 2008.

[3] 

S.C. Sekhar, R. Michaely, R.A. Leitgeb, M. Unser, "Theoretical Analysis of Complex-Conjugate-Ambiguity Suppression in Frequency-Domain Optical-Coherence Tomography," Proceedings of the Fifth IEEE International Symposium on Biomedical Imaging: From Nano to Macro (ISBI'08), Paris, France, May 14-17, 2008, pp. 396-399.

[4] 

S.C. Sekhar, M. Unser, "Performance Analysis of the Cepstral Technique for Frequency-Domain Optical-Coherence Tomography," Proceedings of the Thirty-Third IEEE International Conference on Acoustics, Speech, and Signal Processing (ICASSP'08), Las Vegas NV, USA, March 30-April 4, 2008, pp. 557-560.

[5] 

C.S. Sekhar, R.A. Leitgeb, A.H. Bachmann, M.A. Unser, "Logarithmic Transformation Technique for Exact Signal Recovery in Frequency-Domain Optical-Coherence Tomography," Proceedings of the SPIE European Conference on Biomedical Optics: Progress in Biomedical Optics and Imaging (ECBO'07), Münich, Federal Republic of Germany, June 17-21, 2007, vol. 6627, pp. 662714-1-662714-6.

[6] 

S.C. Sekhar, R.A. Leitgeb, M.L. Villiger, A.H. Bachmann, T. Blu, M. Unser, "Non-Iterative Exact Signal Recovery in Frequency Domain Optical Coherence Tomography," Proceedings of the Fourth IEEE International Symposium on Biomedical Imaging: From Nano to Macro (ISBI'07), Arlington VA, USA, April 12-15, 2007, pp. 808-811.

[7] 

R.A. Leitgeb, R. Michaely, T. Lasser, S.C. Sekhar, "Complex Ambiguity-Free Fourier Domain Optical Coherence Tomography through Transverse Scanning," Optics Letters, vol. 32, no. 23, pp. 3453-3455, December 2007.

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