Bachelor Semester Project
Section of Computer Science, EPFL
Asymmetric division is crucial for the development of multicellular organisms. The embryo of the nematode C. elegans
is a well-suited model system to analyze the mechanisms of asymmetric cell division. Using spinning disc confocal
microscopy, we performed live imaging of green fluorescent-tagged force generation proteins of C. elegans zygotes.
This revealed that such proteins form dynamic fiber-like structures as well as foci. This student project entails
designing image-analysis algorithms and applying these methods to monitor the behavior of these structures in a
quantitative manner over the sequence of images. The project will be implemented in Java as a ImageJ plugin.
Collaboration with Melina Scholze, Gonczy Lab (http://gonczy-lab.epfl.ch)