Biomedical Imaging GroupSTI
English only   BIG > Publications > Laser Doppler Imaging

 Home Page
 News & Events
 Tutorials and Reviews
 Download Algorithms

 All BibTeX References

Full-Field Laser-Doppler Imaging and Its Physiological Significance for Tissue Blood Perfusion

T. Binzoni, D. Van De Ville

Physics in Medicine and Biology, vol. 53, no. 23, pp. 6673-6694, December 7, 2008.

Using Monte Carlo simulations for a semi-infinite medium representing a skeletal muscle tissue, it is demonstrated that the zero- and first-order moments of the power spectrum for a representative pixel of a full-field laser-Doppler imager behave differently from classical laser-Doppler flowmetry. In particular, the zero-order moment has a very low sensitivity to tissue blood volume changes, and it becomes completely insensitive if the probability for a photon to interact with a moving red blood cell is above 0.05. It is shown that the loss in sensitivity is due to the strong forward scatter of the propagating photons in biological tissues (i.e., anisotropy factor g = 0.9). The first-order moment is linearly related to the root mean square of the red blood cell velocity (the Brownian component), and there is also a positive relationship with tissue blood volume. The most common physiological interpretation of the first-order moment is as tissue blood volume times expectation of the blood velocity (in probabilistic terms). In this sense, the use of the first-order moment appears to be a reasonable approach for qualitative real-time blood flow monitoring, but it does not allow us to obtain information on blood velocity or volume independently. Finally, it is shown that the spatial and temporal resolution trade-off imposed by the CMOS detectors, used in full-field laser-Doppler hardware, may lead to measurements that vary oppositely with the underlying physiological quantities. Further improvements on detectors' sampling rate will overcome this limitation.

AUTHOR="Binzoni, T. and Van De Ville, D.",
TITLE="Full-Field Laser-{D}oppler Imaging and Its Physiological
        Significance for Tissue Blood Perfusion",
JOURNAL="Physics in Medicine and Biology",
month="December 7,",

© 2008 IOP. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from IOP.
This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder.