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Effect of Ageing on Elastin Functionality in Human Cerebral Arteries

E. Fonck, G.G. Feigl, J. Fasel, D. Sage, M. Unser, D.A. Rüfenacht, N. Stergiopulos

Proceedings of the ASME 2008 Summer Bioengineering Conference (SBC'08), Marco Island FL, USA, June 25-29, 2008, pp. SBC2008-192727-1/2.



The ageing process affects elastin, a key component of the arterial wall integrity and functionality. Elastin may play an important role in cerebral vessels because elastin degradation is linked to cerebrovascular disease [1]. The goal of this study is to assess the biomechanical properties of human cerebral arteries, their composition and geometry, with particular focus on the functional alterations of elastin in cerebral arteries due to ageing.

References

  1. J. Atkinson, "Aging of Arterial Extracellular Matrix Elastin: Etiology and Consequences,". Pathologie Biologie, vol 46, no. 7, pp. 555-559, September 1998.


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