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Effect of the Bolus Size on the Quantification of Myocardial Perfusion Using MRI

M. Ivancevic, J.-L. Daire, M. Kocher, A. Righetti, D. Didier, J.-P. Vallée

Proceedings of the SCMR Eleventh Annual Scientific Sessions (SCMR'08), Los Angeles CA, USA, February 1-3, 2008, pp. 421-422.



A limitation of MRI for cardiac perfusion on routine clinical MR scanners is the trade-off between the temporal resolution and spatial coverage. Assuming that a higher contrast media dose and a slower injection rate allow lower sampling rate without a significant loss of precision in an one compartmental model, we performed a simulation study to compare two contrast injection strategies (wide and narrow bolus). The validity of the protocol was then demonstrated in patients with a history of myocardial infarction, using 201-Tl SPECT imaging as reference.


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