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Assessment of Chromosomal Length Variation in CHO Cells

P.O. Michel, R. Delgado-Gonzalo, M. Hubert, L. Baldi, D.L. Hacker, M. Unser, F.M. Wurm

Proceedings of the Twenty-Third Meeting of the European Society for Animal Cell Technology (ESACT'13), Lille, French Republic, June 23-26, 2013, pp. 206.



Chinese hamster ovary (CHO)-derived cells are widely used for the production of recombinant proteins. Currently, the pharmaceutical industry relies on stable cell clones for therapeutic protein production. Most of the currently used methods to analyze clonality and stability in recombinant cell lines only take into consideration the cellular phenotype. However, few rapid methods are available to study clonality and genomic stability in recombinant cell populations.


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