EPFL | Biomedical Imaging Group | Radiology Biomarkers

Web-Based Tools for Exploring the Potential of Quantitative Imaging Biomarkers in Radiology: Intensity and Texture Analysis on the ePAD Platform

R. Schaer, Y.D. Cid, E. Alkim, S. John, D.L. Rubin, A. Depeursinge

Biomedical Texture Analysis, A. Depeursinge, O.S. Al-Kadi, J.R. Mitchell, Eds., Academic Press, London, United Kingdom, ch. 13, pp. 379-410, 2017.

Recent papers in the field of radiomics showed strong evidence that novel image biomarkers based on structural tissue properties have the potential to complement and even surpass invasive and costly biopsy-based molecular assays in certain clinical contexts. To date, very few translations of these research results to clinical practive have been carried out. In addition, a majority of the identified imaging biomarkers are perceived as black boxes by end-users, hindering their acceptance in clinical and research environments. We present a suite of plugins called Quantitative Feature Explore (QFExplore) for the open-access cloud-based ePAD platform enabling the exploration and validation of new imaging biomarkers in a clinical environment. The latter include the extraction, visualization and comparison of intensity- and texture-based quantitative imaging features, regional division of regions of interest to reveal tissue diversity, as well as the construction, use and sharing of user-personalized statistical machine learning models. No software installation is required and the platform can be accessed through any web browser. The relevance of the developed tools is demonstrated in the context of various clinical use-cases. The software is available online.

@INCOLLECTION(http://bigwww.epfl.ch/publications/schaer1701.html,
AUTHOR="Schaer, R. and Cid, Y.D. and Alkim, E. and John, S. and Rubin,
	D.L. and Depeursinge, A.",
TITLE="Web-Based Tools for Exploring the Potential of Quantitative
	Imaging Biomarkers in Radiology: {I}ntensity and Texture Analysis on
	the {ePAD} Platform",
BOOKTITLE="Biomedical Texture Analysis",
PUBLISHER="Academic Press",
YEAR="2017",
editor="Depeursinge, A. and Al-Kadi, O.S. and Mitchell, J.R.",
volume="",
series="",
type="",
chapter="13",
pages="379--410",
address="London, United Kingdom",
edition="",
month="",
note="")

© 2017 Academic Press. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from Academic Press. This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder.