Biomedical Imaging GroupSTI
English only   BIG > Publications > EPFL Thesis 3049

 Home Page
 News & Events
 Tutorials and Reviews
 Download Algorithms

 All BibTeX References

Myocardial Motion and Deformation Analysis from Echocardiograms

M. Sühling

Swiss Federal Institute of Technology Lausanne, EPFL Thesis no. 3049 (2004), 181 p., July 16, 2004.


Echocardiography is a widely used imaging technique to examine myocardial function in patients with known or suspected heart disease. The analysis of ventricular wall motion and deformation, in particular, allows to assess the extent of myocardial ischemia and infarction. In clinical practice, the analysis mainly relies on visual inspection or manual measurements by experienced cardiologists. Manual methods are tedious and time-consuming, and visual assessment leads to qualitative and subjective diagnoses that suffer from considerable inter- and intraobserver variability. Automating the analysis of echocardiographic images is therefore highly desirable but also challenging because of the low image quality and the high amount of speckle noise. In this thesis, we propose a framework for robust and quantitative analysis of echocardiographic sequences. We make the following key contributions:

Motion and Deformation Analysis—We propose a novel optical-flow-based algorithm to estimate ventricular wall motion from B-mode echocardiograms. To account for typical heart motions such as contraction/expansion and shear, we use a local affine model for the velocity in space and time. An attractive feature of the affine motion model is that it gives also access to local strain rate parameters that describe local myocardial deformation such as wall thickening. The motion parameters are estimated in the least-squares sense within a sliding spatio-temporal B-spline window. The estimation of large motions is made possible through the use of a coarse-to-fine multi-scale strategy, which also adds robustness to the method.

Computational Efficiency—We introduce the notion of multiresolution moment filters, a novel filtering scheme to compute local weighted geometric moments efficiently at dyadic scales by using a wavelet-like algorithm. Beyond their application in motion analysis, we demonstrate their usefulness for image denoising and feature extraction.

Multi-Modality—We extend the proposed motion analysis algorithm by integrating directional, Doppler-based velocity measurements. The exploitation of two ultrasound modalities, i.e., B-mode and tissue Doppler, renders the method more accurate and robust.

Visualization—We display diagnostically meaningful motion data inside a user-defined region of interest that is tracked in time. Myocardial inward and outward motion is visualized by color coding the radial motion component with respect to the ventricular center. Two-dimensional strain rate information is superimposed in the form of deforming ellipses. The display allows a more intuitive and simplified identification of regions with abnormal motion patterns.

Validation—The proposed method is validated on 1) synthetic data, 2) real ultrasound phantom data, and 3) clinical echocardiograms. A large-scale validation study that includes 114 patients confirms its ability to detect and quantify wall motion abnormalities.

AUTHOR="S{\"{u}}hling, M.",
TITLE="Myocardial Motion and Deformation Analysis from Echocardiograms",
SCHOOL="{S}wiss {F}ederal {I}nstitute of {T}echnology {L}ausanne
type="{EPFL} Thesis no.\ 3049 (2004), 181 p.",
month="July 16,",

© 2004 M. Sühling. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from M. Sühling.
This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder.