Biocartis engages in the development of novel diagnostics technology platforms for multiplex detection of biomarkers. The detection technology is based on encoded micro-particles, which are bio-functionalized and arrayed in a micro-fluidic cartridge for rapid and quantitative capture of target analytes in patient’s sample. Image analysis is used to localize and identify the micro-particles, as well as for fluorescence quantification. In this context, new algorithms of image analysis have to be evaluated and optimized in order to improve the performance of the image analysis system and to define the minimal requirements (focus quality, resolution) of the image acquisition.

The project aims for designing and implementing (Java/ImageJ) dedicated filters to enable image analysis on defocused images. The proposed algorithms will be validated and evaluated on real data.

This work will be done in collaboration with Mathieu Gaillard from Biocartis S.A., Quartier de l'Innovation, EPFL.