BIOMEDICAL IMAGING GROUP (BIG)
Laboratoire d'imagerie biomédicale (LIB)

A Silicon-Pixel Paradigm for PET

A. Boquet-Pujadas, J. Saidi, M. Vicente, L. Paolozzi, J. Dong, P. del Aguila Pla, G. Iacobucci, M. Unser

IEEE Transactions on Radiation and Plasma Medical Sciences, vol. 9, no. 2, pp. 228–246, February 2025.

Positron emission tomography (PET) scanners use scintillation crystals to stop high-energy photons. The ensuing lower-energy photons are then detected via photomultipliers. We study the performance of a stack of monolithic silicon-pixel detectors as an alternative to the combination of crystals and photomultipliers. The resulting design allows for pitches as small as 100 μm and greatly mitigates depth-of-interaction problems. We develop a theory to optimize the sensitivity of these and other scanners under design constraints. The insight is complemented by Monte Carlo simulations and reconstructions thereof. Experiments and theory alike suggest that our approach has the potential to move PET closer to the microscopic scale. The volumetric resolution is an order of magnitude better than that of the state of the art and the parallax error is very small. A small-animal scanner is now under construction. 

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AUTHOR="Boquet-Pujadas, A. and Saidi, J. and Vicente, M. and Paolozzi,
	L. and Dong, J. and del Aguila Pla, P. and Iacobucci, G. and Unser,
	M.",
TITLE="A Silicon-Pixel Paradigm for {PET}",
JOURNAL="{IEEE} Transactions on Radiation and Plasma Medical Sciences",
YEAR="2025",
volume="9",
number="2",
pages="228--246",
month="February",
note="")

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