Fundamental Bounds on the Precision of 3D Localization in Coherent and Incoherent Microscopy
J. Dong, D. Maestre, C. Conrad-Billroth, T. Juffmann
Single Molecule Localization Microscopy Symposium (SMLMS'21), Lausanne VD, Swiss Confederation, August 31-September 2, 2021.
Localization microscopy is now ubiquitous for high-resolution optical imaging. However, the number of observed photons for one position estimation is finite, which limits the achievable resolution. These shot-noise-limited measurements induce fluctuations in the estimated position, that we can quantify with the Cramér-Rao bounds (CRB) on estimation precision.
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