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Fundamental Bounds on the Precision of 3D Localization in Coherent and Incoherent Microscopy

J. Dong, D. Maestre, C. Conrad-Billroth, T. Juffmann

Single Molecule Localization Microscopy Symposium (SMLMS'21), Lausanne VD, Swiss Confederation, August 31-September 2, 2021.


Localization microscopy is now ubiquitous for high-resolution optical imaging. However, the number of observed photons for one position estimation is finite, which limits the achievable resolution. These shot-noise-limited measurements induce fluctuations in the estimated position, that we can quantify with the Cramér-Rao bounds (CRB) on estimation precision.

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TITLE="Fundamental Bounds on the Precision of {3D} Localization in
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