To have a better understanding of the cell functionning, the molecular biologists record 3D movies of the cell division. The chromosome are GFP tagged (fluoresence). At the beginning of cell division cycle the chromatin is distributed relatively homogenously, but condenses to small aggregates that grow in size during prophase. The objective of this project is to find features that quantitatively correlates with chromatin condensation in prophase. The student have to define the right measurements in collaboration with the biologists. These measures have to take account all dimensions (3D+time). The implementation is in Java as a plugin of ImageJ.

Collaboration: Daniel Gerlich and Jan Ellenberg, Gene Expression and Cell Biology, European Molecular Biology Laboratory EMBL, Heidelberg, Germany